Water → 3-[4-(4-Fluorophenoxy)benzyloxy]piperidine

HRID 602186Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 602186
[OH-].[K+].FC(F)(F)C([N:7]1[CH2:12][CH2:11][CH2:10][CH:9]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)=[CH:17][CH:16]=2)[CH2:8]1)=O.O>CO>[F:28][C:25]1[CH:26]=[CH:27][C:22]([O:21][C:18]2[CH:17]=[CH:16][C:15]([CH2:14][O:13][CH:9]3[CH2:10][CH2:11][CH2:12][NH:7][CH2:8]3)=[CH:20][CH:19]=2)=[CH:23][CH:24]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 589925921-Trifluoroacetyl-3-[4-(4-fluorophenoxy)benzyloxy]piperidine

Produkt 1

HCID 589926953-[4-(4-Fluorophenoxy)benzyloxy]piperidineAusbeute 95,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A 1 mol/L aqueous potassium hydroxide solution (2 mL) was added to 1-trifluoroacetyl-3-[4-(4-fluorophenoxy)benzyloxy]piperidine (434 mg, 1.09 mmol) in methanol (4 mL). The mixture was refluxed for 2 hours and was allowed to cool. Water was then added and the mixture was extracted with ethyl acetate. The organic layer was washed with brine and the washed product was dried over magnesium sulfate. The solvent was evaporated to give 314 mg (95%) of the desired compound as a colorless oil.

Aufarbeitung

  1. temperatureThe mixture was refluxed for 2 hours
  2. temperatureto cool
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with brine
  5. dry with materialthe washed product was dried over magnesium sulfate
  6. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-595462e0dfde48798d401963a45daa78
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07902367B2

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