Oxalyl chloride → Methyl 5-bromopyrimidine-4-carboxylate

HRID 604353Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 604353
[Br:1][C:2]1[C:3]([C:8]([OH:10])=[O:9])=[N:4][CH:5]=[N:6][CH:7]=1.[C:11](Cl)(=O)C(Cl)=O>C(Cl)Cl.CN(C=O)C>[CH3:11][O:9][C:8]([C:3]1[C:2]([Br:1])=[CH:7][N:6]=[CH:5][N:4]=1)=[O:10]

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 213292005-Bromopyrimidine-4-carboxylic acid

Produkt 1

HCID 45790077Methyl 5-bromopyrimidine-4-carboxylateAusbeute 39 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

5-Bromopyrimidine-4-carboxylic acid (prepared according to the procedure described in U.S. Pat. No. 4,110,450) (1.0 eq, 6.14 g, 30.2 mmol) was suspended in CH2Cl2 (100 ml). Oxalylchloride (1.1 eq, 2.9 ml, 33.0 mmol) was added followed by 2 drops of DMF. The mixture was stirred at room temperature overnight and the volatiles were removed in vacuo. The residue was taken in MeOH (50 ml) and heated. After evaporation of MeOH in vacuo the compound was dissolved in CH2Cl2 and poured on a prepacked silica gel column. The material was eluted using 20% Ethyl acetate in hexanes. Evaporation of the solvent provided methyl-5-bromopyrimidine-4-carboxylate as a light orange crystalline solid (2.54 g, 39% yield). LCMS (ES): 95% pure, m/z 217 [M]+; 219 [M+2]+; 1H NMR (CDCl3, 400 MHz) δ 4.04 (s, 3H), 9.02 (s, 1H), 9.21 (s, 1H) ppm.

Aufarbeitung

  1. customthe volatiles were removed in vacuo
  2. temperatureheated
  3. customAfter evaporation of MeOH in vacuo the compound
  4. dissolutionwas dissolved in CH2Cl2
  5. additionpoured on a prepacked silica gel column
  6. washThe material was eluted
  7. customEvaporation of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-89fd55d6d0164a549434408a8c0c9bff
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07910600B2

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