Hydrochloric Acid → 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-furan-2-yl-1H-pyrazole-3-carboxylic acid

HRID 604423

Reaktionsgleichung

Reaktionsgleichung von HRID 604423
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[O:12][CH:13]=[CH:14][CH:15]=2)[N:8]([CH2:16][C:17]2[CH:21]=[C:20]([C:22]3[S:23][C:24]([Cl:27])=[CH:25][CH:26]=3)[O:19][N:18]=2)[N:7]=1)=[O:5])C.Cl>C1COCC1.O.[OH-].[Na+]>[Cl:27][C:24]1[S:23][C:22]([C:20]2[O:19][N:18]=[C:17]([CH2:16][N:8]3[C:9]([C:11]4[O:12][CH:13]=[CH:14][CH:15]=4)=[CH:10][C:6]([C:4]([OH:5])=[O:3])=[N:7]3)[CH:21]=2)=[CH:26][CH:25]=1

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 602079551-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-furan-2-yl-1H-pyrazole-3-carboxylic acid ethyl ester

Produkt 1

HCID 230334811-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-furan-2-yl-1H-pyrazole-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

To a solution of 400 mg 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-furan-2-yl-1H-pyrazole-3-carboxylic acid ethyl ester in 5 ml THF and 1 ml water, 1 ml aqueous NaOH (1M) were added and the mixture was stirred for 16 h at RT. Then the solution was acidified to pH 3 with half concentrated hydrochloric acid to precipitate the pure product, which was collected by filtration. Yield: 360 mg.

Aufarbeitung

  1. customto precipitate the pure product, which
  2. filtrationwas collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-46371ecfa0754c6fbf89add5801f004d
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07910606B2

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