Hydrochloric Acid → 5-Chloro-4-nitrothiophene-2-carboxylic acid

HRID 605316Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 605316
C([O:3][C:4]([C:6]1[S:7][C:8]([Cl:14])=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)=[O:5])C.[OH-].[Li+].Cl>CO.O>[Cl:14][C:8]1[S:7][C:6]([C:4]([OH:5])=[O:3])=[CH:10][C:9]=1[N+:11]([O-:13])=[O:12]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 56763846HCID 56763846, Verbindung

Produkt 1

HCID 132055635-Chloro-4-nitrothiophene-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 22242641Methanol--water (1/1)Lösungsmittel

Versuchsvorschrift

The product from Example 351A (1 equiv) was dissolved in a methanol/water 3/1 mixture followed by the addition of lithium hydroxide (5 equiv). The resultant solution was stirred at room temperature for 24 hours followed by the addition of 1N aqueous hydrochloric acid until the solution was a pH of 2. The mixture was then extracted with ethyl acetate, the organic extracts dried and concentrated under vacuum to provide the title product.

Aufarbeitung

  1. extractionThe mixture was then extracted with ethyl acetate
  2. customthe organic extracts dried
  3. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-8671b14d8ae14514951ecdd76cc41574
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07910595B2

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