Lithium Hydroxide → 3-Methyl-5-(4-methyl-morpholin-2-ylmethoxy)-benzofuran-2-carboxylic acid
Reaktionsgleichung
[CH3:1][C:2]1[C:6]2[CH:7]=[C:8]([O:11][CH2:12][CH:13]3[O:18][CH2:17][CH2:16][N:15]([CH3:19])[CH2:14]3)[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:20]([O:22]CC)=[O:21].[OH-].[Li+]>O1CCCC1>[CH3:1][C:2]1[C:6]2[CH:7]=[C:8]([O:11][CH2:12][CH:13]3[O:18][CH2:17][CH2:16][N:15]([CH3:19])[CH2:14]3)[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:20]([OH:22])=[O:21]Komponenten
4
Versuchsvorschrift
Ethyl 3-methyl-5-(4-methyl-morpholin-2-ylmethoxy)-benzofuran-2-carboxylate (0.12 mmol) was dissolved in 300 μl of tetrahydrofuran. Then 300 μl of a 1.0 M solution of lithium hydroxide were added and the mixture stirred at room temperature for 3 hours. The tetrahydrofuran was removed under vacuo and the water eliminated by lyophilisation to yield the tilted compound as a white solid: m/z=304 in MS ES−.