Hydrochloric Acid → 3-Methyl-5-phenylethynylpyridine hydrochloride
Reaktionsgleichung
[ClH:1].[CH3:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:8]=1>O1CCOCC1.C(OCC)C>[ClH:1].[CH3:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:8]=1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
Add a 4 N solution of hydrogen chloride in 1,4-dioxane (0.6 mL) to a solution of 3-methyl-5-phenylethynylpyridine (0.398 g, 2.06 mmol), (prepared essentially as described in EXAMPLE 1), in diethyl ether (2 mL). Concentrate the reaction mixture and triturate the resulting solid with hexanes and diethyl ether to give the title compound as a solid (0.477 mg, 100%).
Aufarbeitung
- custom(prepared essentially
- concentrationConcentrate the reaction mixture
- customtriturate the resulting solid with hexanes and diethyl ether
Quellen und Nachweise
- ORD-Eintrag
- ord-5ce516976ecf47aeacdc404f9ef9b176
- Quelldatensatz
- uspto-grants-2011_03
- Patentnummer
- US07915424B2
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