(4-(Cyclopentylcarbamoyl)phenyl)boronic acid → Biphenyl

HRID 608097

Reaktionsgleichung

Reaktionsgleichung von HRID 608097
CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)OC(C)(C)C)CC2)c2cc(Cl)c(C)cc21.CN(C)C(=NC(C)(C)C)N(C)C.O=C(NC1CCCC1)c1ccc(B(O)O)cc1>CCC(C)(C)O.CN(C)c1ccc([PH](C(C)(C)C)(C(C)(C)C)[Pd]2([O]S(C)(=O)=O)[NH]c3ccccc3-c3cccc[c]32)cc1.CS(C)=O.O>CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)OC(C)(C)C)CC2)c2cc(-c3ccc(C(=O)NC4CCCC4)cc3)c(C)cc21

Komponenten

10

Edukt 2

HCID 2773358(4-(Cyclopentylcarbamoyl)phenyl)boronic acidHCID 24805585tert-Butyl (R)-3-(2-acetamidopropan-2-yl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

Produkt 3

HCID 7095BiphenylHCID 24805585tert-Butyl (R)-3-(2-acetamidopropan-2-yl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylateHCID 178474758HCID 178474758, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 5

HCID 178482905HCID 178482905, VerbindungKatalysatorHCID 679Dimethyl SulfoxideLösungsmittel3×HCID 962WaterLösungsmittelHCID 64052-Methyl-2-butanolLösungsmittelHCID 35715812-tert-Butyl-1,1,3,3-tetramethylguanidineSonstige

Aufarbeitung

  1. additionAfter 22 hours the crude reactions were diluted with 3 x 1 uL 0.5 M AcOH in DMSO (containing PhPh as an internal standard). The reactions were mixed after each dispense operation.
  2. aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis.

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