(4-(Cyclopentylcarbamoyl)phenyl)boronic acid → Biphenyl

HRID 608100Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 608100
CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)OC(C)(C)C)CC2)c2cc(Cl)c(C)cc21.CC(C)(C)N=P(N1CCCC1)(N1CCCC1)N1CCCC1.O=C(NC1CCCC1)c1ccc(B(O)O)cc1>CC(C)(C)[PH](C(C)(C)C)(C(C)(C)C)[Pd]1([Cl])[NH]c2ccccc2-c2cccc[c]21.CCC(C)(C)O.CS(C)=O.O>CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)OC(C)(C)C)CC2)c2cc(-c3ccc(C(=O)NC4CCCC4)cc3)c(C)cc21

Komponenten

10

Edukt 2

HCID 2773358(4-(Cyclopentylcarbamoyl)phenyl)boronic acidHCID 24805585tert-Butyl (R)-3-(2-acetamidopropan-2-yl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

Produkt 3

HCID 7095BiphenylHCID 24805585tert-Butyl (R)-3-(2-acetamidopropan-2-yl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylateHCID 178474758HCID 178474758, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 5

HCID 178454896HCID 178454896, VerbindungKatalysatorHCID 679Dimethyl SulfoxideLösungsmittel3×HCID 962WaterLösungsmittelHCID 64052-Methyl-2-butanolLösungsmittelHCID 3856267tert-Butylimino-tri(pyrrolidino)phosphoraneSonstige

Aufarbeitung

  1. additionAfter 22 hours the crude reactions were diluted with 3 x 1 uL 0.5 M AcOH in DMSO (containing PhPh as an internal standard). The reactions were mixed after each dispense operation.
  2. aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis.

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