N,N-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline → Biphenyl

HRID 608675Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 608675
CCN=P(N=P(N(C)C)(N(C)C)N(C)C)(N(C)C)N(C)C.CCn1c(=O)c2c(nc(N[C@@H]3CCC[C@H]3O)n2Cc2ccc(OC)c(Br)c2)n(CCO)c1=O.CN(C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1>CN(C)c1ccc([PH](C(C)(C)C)(C(C)(C)C)[Pd]2([O]S(C)(=O)=O)[NH]c3ccccc3-c3cccc[c]32)cc1.CS(C)=O.O>CCn1c(=O)c2c(nc(N[C@@H]3CCC[C@H]3O)n2Cc2ccc(OC)c(-c3ccc(N(C)C)cc3)c2)n(CCO)c1=O

Komponenten

9

Edukt 2

HCID 2758659N,N-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)anilineHCID 9871410Dasantafil

Produkt 3

HCID 7095BiphenylHCID 9871410DasantafilHCID 178462858HCID 178462858, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 178482905HCID 178482905, VerbindungKatalysatorHCID 679Dimethyl SulfoxideLösungsmittel4×HCID 962WaterLösungsmittelHCID 33931062,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineSonstige

Aufarbeitung

  1. additionAfter 22 hours the crude reactions were diluted with 3 x 1 uL 0.5 M AcOH in DMSO (containing PhPh as an internal standard). The reactions were mixed after each dispense operation.
  2. aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis.

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