Putrescine → 2-(4-Aminobutyl)amino-2-methyl-3-pentanone oxime

HRID 609513Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 609513
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][NH2:6].C(N(CC)CC)C.Cl[C:15]([CH3:22])([CH:17]([N:20]=[O:21])[CH2:18][CH3:19])[CH3:16]>C(#N)C>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:15]([CH3:22])([C:17](=[N:20][OH:21])[CH2:18][CH3:19])[CH3:16]

Komponenten

5

Edukt 3

HCID 1045PutrescineHCID 8471TriethylamineHCID 122253792-Chloro-2-methyl-3-nitrosopentane

Produkt 1

HCID 867548932-(4-Aminobutyl)amino-2-methyl-3-pentanone oxime

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel2×

Versuchsvorschrift

To a stirred solution of 1,4-diaminobutane (0.26 g; 2.9 mmol) and triethylamine (0.33 g; 3.2 mmol) in acetonitrile (5 ml) was added a solution of 2-chloro-2-methyl-3-nitrosopentane (0.485 g; 3.24 mmol) in acetonitrile (5 ml). After stirring for ca 10 minutes the product began to precipitate. The reaction mixture was stirred overnight and the product was filtered off and dried in vacuo to give a white powder, (0.5 g; 86%).

Aufarbeitung

  1. customto precipitate
  2. stirringThe reaction mixture was stirred overnight
  3. filtrationthe product was filtered off
  4. customdried in vacuo
  5. customto give a white powder, (0.5 g; 86%)

Quellen und Nachweise

ORD-Eintrag
ord-0549a6c25ee74ecd8c17146f962ea5db
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US05997843

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