3-(4-Methoxyphenyl)-2-methylpropanoic acid → 6-Methoxy-2-methyl-2,3-dihydro-1H-inden-1-one

HRID 610089Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 610089
[CH3:1][CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)[C:3]([OH:5])=O>O>[CH3:14][O:13][C:10]1[CH:11]=[C:12]2[C:7]([CH2:6][CH:2]([CH3:1])[C:3]2=[O:5])=[CH:8][CH:9]=1

Komponenten

3

Edukt 1

HCID 105358043-(4-Methoxyphenyl)-2-methylpropanoic acid

Produkt 1

HCID 2311786-Methoxy-2-methyl-2,3-dihydro-1H-inden-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
86.5 °C

Versuchsvorschrift

α-Methyl-β-(p-methoxyphenyl)propionic acid (15 g) is added to polyphosphoric acid (170 g) at 50° C. and the mixture is heated at 83-90° C. for two hours. The syrup is poured into iced water, stirred for one-half hour, and then extracted with ether three times. The ether solution is washed with water twice, and with 5% NaHCO3 five times until all the acidic material has been removed. The remaining neutral solution is washed with water and dried over sodium sulfate. Evaporation of the solution gives the indanone as a pale yellow oil.

Aufarbeitung

  1. extractionextracted with ether three times
  2. washThe ether solution is washed with water twice
  3. customwith 5% NaHCO3 five times until all the acidic material has been removed
  4. washThe remaining neutral solution is washed with water
  5. dry with materialdried over sodium sulfate
  6. customEvaporation of the solution

Quellen und Nachweise

ORD-Eintrag
ord-b11cca8d8a784803ac48e444f07247f4
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US05998477

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