Anthranilic Acid → Acetanthranil

HRID 610472

Reaktionsgleichung

Reaktionsgleichung von HRID 610472
[C:1]([OH:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[C:11](OC(=O)C)(=O)[CH3:12]>>[CH3:11][C:12]1[O:9][C:1](=[O:10])[C:2]2[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=2[N:4]=1

Komponenten

3

Edukt 2

HCID 227Anthranilic AcidHCID 7918Acetic Anhydride

Produkt 1

HCID 68236Acetanthranil

Versuchsvorschrift

Anthranilic acid (274.3 g) and acetic anhydride (1.1 L) were combined then heated at reflux for 3.5 hours. The reaction mixture was concentrated under vacuum. The residue was combined with methanol (550 mL) then concentrated under vacuum to provide 2-methyl-4-oxo-3,1-benzoxazine as a brown oil.

Aufarbeitung

  1. temperatureat reflux for 3.5 hours
  2. concentrationThe reaction mixture was concentrated under vacuum
  3. concentrationthen concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-ffac392fa140465e953adccd91308e75
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US05998619

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