Peracetic Acid → Cyclohexanecarboxylic acid

To a stirred solution of 5.0 g (44.6 mmol) of cyclohexanecarboxaldehyde in n-butyl acetate (45 mL) cooled in a wet-ice bath (ca. 2° C.) was added 5.5 g (44.6 mmol) of 2,6-dimethylpyridine N-oxide (2,6-lutidine N-oxide). To this solution was then added slowly dropwise 24.6 mL (66.9 mmol) of a 23.0 weight percent solution of peracetic acid in ethyl acetate, at a rate slow enough such that the reaction temperature did not exceed 10° C. (ca. 20 min). After the initial exotherm, the temperature returned to 2° C., and the reaction was maintained at this temperature for an additional 4 hours. The cold reaction solution Was then transferred into a separatory funnel, was diluted with n-butyl acetate (50 mL), and was washed with a 1% aqueous solution of sodium thiosulfate (Na2S2O3, 50 mL). The butyl acetate layer was further washed with two portions of water (50 mL each), and the combined water washes were back-extracted with n-butyl acetate (50 ml). The combined butyl acetate layers were extracted with two portions of a 5% aqueous solution of sodium hydroxide (NaOH, 50 mL each). The combined NaOH solutions were acidified to pH=1 with a 10% aqueous solution of hydrochloric acid. The resulting solution was extracted with two portions of dichloromethane (75 mL each), and the extract was dried over anhydrous Na2SO4. The extract was filtered and concentrated in vacuo to give 6.0 g (99%) of cyclohexanecarboxylic acid, containing small levels of unidentified impurities.

1. customdid not exceed 10° C.
2. custom(ca. 20 min)
3. customreturned to 2° C.
4. temperaturethe reaction was maintained at this temperature for an additional 4 hours
5. customThe cold reaction solution Was then transferred into a separatory funnel
6. washwas washed with a 1% aqueous solution of sodium thiosulfate (Na2S2O3, 50 mL)
7. washThe butyl acetate layer was further washed with two portions of water (50 mL each)
8. extractionthe combined water washes were back-extracted with n-butyl acetate (50 ml)
9. extractionThe combined butyl acetate layers were extracted with two portions of a 5% aqueous solution of sodium hydroxide (NaOH, 50 mL each)
10. extractionThe resulting solution was extracted with two portions of dichloromethane (75 mL each)
11. dry with materialthe extract was dried over anhydrous Na2SO4
12. filtrationThe extract was filtered
13. concentrationconcentrated in vacuo

ORD-Eintrag

ord-f23b1ff0098c40e8b05befe1915f01c6

Quelldatensatz

uspto-grants-1999_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05998660