Ammonium Chloride → 5-(4-Aminophenyl)-4-chloro-7-isopropylpyrrolo[2,3-d]pyrimidine

HRID 611532Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 611532
[Cl:1][C:2]1[C:3]2[C:10]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=3)=[CH:9][N:8]([CH:20]([CH3:22])[CH3:21])[C:4]=2[N:5]=[CH:6][N:7]=1.[Cl-].[NH4+]>[Fe].O>[NH2:17][C:14]1[CH:15]=[CH:16][C:11]([C:10]2[C:3]3[C:2]([Cl:1])=[N:7][CH:6]=[N:5][C:4]=3[N:8]([CH:20]([CH3:22])[CH3:21])[CH:9]=2)=[CH:12][CH:13]=1

Komponenten

5

Edukt 2

HCID 25517Ammonium ChlorideHCID 195974814-Chloro-7-isopropyl-5-(4-nitrophenyl)pyrrolo[2,3-d]pyrimidine

Produkt 1

HCID 195974875-(4-Aminophenyl)-4-chloro-7-isopropylpyrrolo[2,3-d]pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 4-chloro-7-isopropyl-5-(4-nitrophenyl)pyrrolo[2,3-d]pyrimidine (1.0 g), iron powder (1.76 g), ammonium chloride (86 mg), water (8 ml) and industrial methylated spirit (40 ml) was boiled under reflux for one hour. The mixture was filtered and the solvent evaporated. The residue was taken up in ethyl acetate and washed with water. The ethyl acetate extract was dried, filtered and evaporated to give 5-(4-aminophenyl)-4-chloro-7-isopropylpyrrolo[2,3-d]pyrimidine.

Aufarbeitung

  1. temperatureunder reflux for one hour
  2. filtrationThe mixture was filtered
  3. customthe solvent evaporated
  4. washwashed with water
  5. extractionThe ethyl acetate extract
  6. customwas dried
  7. filtrationfiltered
  8. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-4836753ec72e49499603987c56851b6e
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US06001839

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