Benzaldehyde → HCID 10704801, Verbindung

HRID 612391

Reaktionsgleichung

Reaktionsgleichung von HRID 612391
[CH2:1]([O:3][C:4](=[O:10])[CH:5]([NH2:9])[CH2:6][CH2:7][CH3:8])[CH3:2].[CH:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(N(CC)CC)C.S([O-])([O-])(=O)=O.[Mg+2]>C(OCC)C>[CH2:1]([O:3][C:4](=[O:10])[CH:5]([N:9]=[CH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:6][CH2:7][CH3:8])[CH3:2]

Komponenten

6

Edukt 4

HCID 240BenzaldehydeHCID 8471TriethylamineHCID 24083Sulfuric acid magnesium salt (1:1)HCID 551577Ethyl 2-aminopentanoate

Produkt 1

HCID 10704801HCID 10704801, VerbindungAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A solution of 11.90 g of the product from stage 1 in 150 ml of diethyl ether was combined in succession with 8.3 ml of benzaldehyde, 23 ml of triethylamine and 7.0 g of anhydrous magnesium sulphate. The mixture was stirred for 24 hours at room temperature, then filtered and washed with diethyl ether. Once the solvent had been removed by distillation, 18.40 g of 2-(benzylideneamino)pentanoic acid ethyl ester (96% of th.) were obtained in the form of a yellowish, viscous mass.

Aufarbeitung

  1. filtrationfiltered
  2. washwashed with diethyl ether
  3. customOnce the solvent had been removed by distillation

Quellen und Nachweise

ORD-Eintrag
ord-609e37ea642247eda6e147a639e8b084
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US06004963

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