2-Hydroxy-3-nitrobiphenyl → 2-Amino-6-phenylphenol

HRID 612720

Reaktionsgleichung

Reaktionsgleichung von HRID 612720
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:5]=1[OH:16])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:5]=1[OH:16]

Komponenten

4

Edukt 1

HCID 1607452-Hydroxy-3-nitrobiphenyl

Produkt 1

HCID 211846892-Amino-6-phenylphenolAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-nitro-6-phenylphenol(900 mg, 4.2 mmol) in methanol(50 ml) was added 10% Pd/C (100 mg). The mixture was flushed with argon, then hydrogen was bubbled through the solution for 10 min. and a hydrogen atmosphere was maintained at balloon pressure overnight. The mixture was filtered through celite and the celite was washed with methanol. The solvent was evaporated and chromatography of the resulting solid on silica gel (5% MeOH/CH2Cl2) gave the desired product(700 mg, 90%). 1H NMR (CD3OD): δ7.55-7.27 (m, 5H), 6.77-6.61 (m, 3H)

Aufarbeitung

  1. customThe mixture was flushed with argon
  2. customhydrogen was bubbled through the solution for 10 min.
  3. temperaturea hydrogen atmosphere was maintained at balloon pressure overnight
  4. filtrationThe mixture was filtered through celite
  5. washthe celite was washed with methanol
  6. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-ef6f16454ae64beda6702efcd8f3d3de
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US06005008

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