Sodium methanethiolate → HCID 19592663, Verbindung

HRID 613465

Reaktionsgleichung

Reaktionsgleichung von HRID 613465
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8](Br)=[CH:7]2.[CH3:13][S-:14].[Na+]>CN(C)C=O.C(OCC)(=O)C>[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([S:14][CH3:13])=[CH:7]2

Komponenten

5

Edukt 2

HCID 4378561Sodium methanethiolateHCID 151125453-Bromoquinolin-8-amine

Produkt 1

HCID 19592663HCID 19592663, VerbindungAusbeute 66,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of 8-amino-3-bromoquinoline (200 mg) and sodium thiomethoxide (109 mg) in N,N-dimethylformamide (2 ml) was stirred at ambient temperature for 2 days. After diluted with ethyl acetate, the resulting mixture was washed with water and brine, dried over anhydrous sodium sulfate, and evaporated in vacuo. The residue was purified by chromatography on silica gel (n-hexane-ethyl acetate) to give 8-amino-3-methylthioquinoline (113 mg) as an oil.

Aufarbeitung

  1. washthe resulting mixture was washed with water and brine
  2. dry with materialdried over anhydrous sodium sulfate
  3. customevaporated in vacuo
  4. customThe residue was purified by chromatography on silica gel (n-hexane-ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-802c2d8881664f5886a4efecce353081
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US06008230

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