Acetic Anhydride → 4-Acetamido-3-methoxybenzyl alcohol

HRID 613595Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 613595
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[O:10][CH3:11].[C:12](OC(=O)C)(=[O:14])[CH3:13]>CO>[C:12]([NH:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[O:10][CH3:11])(=[O:14])[CH3:13]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 53420748(4-Amino-3-methoxyphenyl)methanol

Produkt 1

HCID 538917484-Acetamido-3-methoxybenzyl alcoholAusbeute 73,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 4-amino-3-methoxybenzyl alcohol (900 mg) in methanol was added acetic anhydride (1.8 g) under ice cooling, and the mixture was stirred for 1 hour at the same temperature. After evaporation, the residue was dissolved in ethyl acetate, and the solution was washed with sodium bicarbonate solution, water and brine, dried over magnesium sulfate and concentrated in vacuo to give 4-acetamido-3-methoxybenzyl alcohol (840 mg) as solid.

Aufarbeitung

  1. customAfter evaporation
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washthe solution was washed with sodium bicarbonate solution, water and brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8912a1a0b9424178a4edcdf5a886c8e5
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US06008229

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