4-Methylmorpholine → N-t-butoxycarbonylglycylglycyl-L-phenylalanine benzyl ester

HRID 614203Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 614203
Cl.[CH2:2]([O:9][C:10](=[O:24])[C@H:11]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[NH:12][C:13](=[O:16])[CH2:14][NH2:15])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.ClC1C=C(Cl)C(Cl)=CC=1[O:34][C:35](=O)[CH2:36][NH:37][C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39].CN1CCOCC1>C(Cl)Cl>[CH2:2]([O:9][C:10](=[O:24])[C@H:11]([CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[NH:12][C:13](=[O:16])[CH2:14][NH:15][C:35](=[O:34])[CH2:36][NH:37][C:38]([O:40][C:41]([CH3:43])([CH3:42])[CH3:44])=[O:39])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Komponenten

5

Edukt 3

HCID 79724-MethylmorpholineHCID 12799284t-Butoxycarbonylglycine-2,4,5-Trichlorophenyl EsterHCID 70603822glycyl-L-phenylalanine benzyl ester hydrochloride

Produkt 1

HCID 54338339N-t-butoxycarbonylglycylglycyl-L-phenylalanine benzyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 6.1 parts glycyl-L-phenylalanine benzyl ester hydrochloride, 7.0 parts N-t-butoxycarbonylglycine 2,4,5-trichlorophenyl ester and 1.8 parts N-methylmorpholine in 150 parts methylene chloride is stirred overnight at room temperature. The solvents are then removed by evaporation under reduced pressure to yield the crude tripeptide. Purification by low pressure column chromatography affords pure N-t-butoxycarbonylglycylglycyl-L-phenylalanine benzyl ester.

Aufarbeitung

  1. customThe solvents are then removed by evaporation under reduced pressure
  2. customto yield the crude tripeptide
  3. customPurification by low pressure column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-51e5c6e633014b468d7fc6b39a0ba378
Quelldatensatz
uspto-grants-1979_03
Patentnummer
US04144228

Notizen zur Reaktion

Wird geladen…