Butyl bromide → HCID 21329306, Verbindung

HRID 614347Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 614347
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([N:10]3[C:14]4=[N:15][CH:16]=[CH:17][CH:18]=[C:13]4[NH:12][C:11]3=[O:19])=[CH:4][C:3]=2[O:2]1.[OH-].[K+].Br[CH2:23][CH2:24][CH2:25][CH3:26]>CC(C)=O>[CH2:23]([N:12]1[C:13]2[C:14](=[N:15][CH:16]=[CH:17][CH:18]=2)[N:10]([C:5]2[CH:6]=[CH:7][C:8]3[O:9][CH2:1][O:2][C:3]=3[CH:4]=2)[C:11]1=[O:19])[CH2:24][CH2:25][CH3:26]

Komponenten

5

Edukt 3

HCID 8002Butyl bromideHCID 14797Potassium HydroxideHCID 119617392H-Imidazo[4,5-b]pyridin-2-one, 3-(1,3-benzodioxol-5-yl)-1,3-dihydro-

Produkt 1

HCID 21329306HCID 21329306, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a suspension of 2.6 g. (0.01 mole) of 1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]-pyridin-2-one in 150 ml. of acetone, was added 1.12 g. (0.02 mole) of powdered potassium hydroxide. The mixture was stirred at room temperature for 20 minutes and 2.74 g. (0.02 mole) of 1-bromobutane was added. The mixture was stirred at reflux for 16 hours and then evaporated in vacuo. The residue was extracted with a solution of 20 ml. of 2.5 N sodium hydroxide and 50 ml. of water. The product was separated by filtration and was purified by crystallization from ether-petroleum ether giving 2.4 g. of white needles melting at 74°-75° C.

Aufarbeitung

  1. additionTo a suspension of 2.6 g
  2. stirringThe mixture was stirred
  3. temperatureat reflux for 16 hours
  4. customevaporated in vacuo
  5. extractionThe residue was extracted with a solution of 20 ml
  6. customThe product was separated by filtration
  7. customwas purified by crystallization from ether-petroleum ether giving 2.4 g

Quellen und Nachweise

ORD-Eintrag
ord-c3ca62fefccb47778086dfc0f31d5ffc
Quelldatensatz
uspto-grants-1979_03
Patentnummer
US04144341

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