Nitric Acid → HCID 12909298, Verbindung

HRID 614527Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 614527
[CH:1]1[N:9]2[C:4]([CH2:5][O:6][C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=32)=[N:3][C:2]=1[C:14]([O:16][CH3:17])=[O:15].S(=O)(=O)(O)O.[N+:23]([O-])([OH:25])=[O:24]>O>[N+:23]([C:11]1[CH:12]=[CH:13][C:7]2[O:6][CH2:5][C:4]3=[N:3][C:2]([C:14]([O:16][CH3:17])=[O:15])=[CH:1][N:9]3[C:8]=2[CH:10]=1)([O-:25])=[O:24]

Komponenten

5

Edukt 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 12909280HCID 12909280, Verbindung

Produkt 1

HCID 12909298HCID 12909298, VerbindungAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

8.0 g of methyl 4H-imidazo-[2,1-c][1,4]-benzoxazine-2-carboxylate were added to a stirred mixture of 25 ml of concentrated sulfuric acid and 25 ml of concentrated nitric acid at 10° C. The ester slowly went into solution with the solution turning yellow and after three hours at room temperature, thin layer chromatography indicated no starting material remained. 500 ml of water were then added and the yellow product thus formed was filtered off, washed well with water and then dried over P2O5 to obtain 7.5 g (79% yield) of methyl 8-nitro-4H-imidazo-[2,1-c][1,4]-benzoxazine-2-carboxylate with a melting point of 270°-2° C.

Aufarbeitung

  1. customthe yellow product thus formed
  2. filtrationwas filtered off
  3. washwashed well with water
  4. dry with materialdried over P2O5

Quellen und Nachweise

ORD-Eintrag
ord-8ada9dd7c86d47a29bfcb9bf802d0b66
Quelldatensatz
uspto-grants-1979_03
Patentnummer
US04145419

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