Diethyl Ether → 2,2-Dimethyl-4-(naphthalen-2-yl)-2H-1-benzopyran-7-ol

HRID 614756

Reaktionsgleichung

Reaktionsgleichung von HRID 614756
[CH3:1][Li].[OH:3][C:4]1C=C2[C:7]([C:8]([C:15]3[CH:24]=[CH:23][C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH:16]=3)=[CH:9]C(=O)O2)=[CH:6][CH:5]=1.[CH3:25][CH2:26][O:27][CH2:28][CH3:29]>>[CH3:25][C:26]1([CH3:1])[CH:9]=[C:8]([C:15]2[CH:24]=[CH:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=2)[C:7]2[C:28](=[CH:29][C:4]([OH:3])=[CH:5][CH:6]=2)[O:27]1

Komponenten

4

Edukt 3

HCID 3283Diethyl EtherHCID 205704957-Hydroxy-4-(naphthalen-2-yl)-2H-1-benzopyran-2-oneHCID 178418348HCID 178418348, Verbindung

Produkt 1

HCID 205705402,2-Dimethyl-4-(naphthalen-2-yl)-2H-1-benzopyran-7-ol

Versuchsvorschrift

To a stirred solution of methyl lithium (0.04 mole, 20 ml of a 1.9M solution in ether) under nitrogen at ambient temperature was added portionwise 7-hydroxy-4-(2-naphthyl)coumarin (2.89 g, 0.01 mole). After 5 hours the solution was decomposed with acid to give 2,2-dimethyl-4-(2-naphthyl)-2H-chromen-7-ol as a crude dark brown foam (2 g) which was used without further purification.

Quellen und Nachweise

ORD-Eintrag
ord-57ea32d852754ecfb4f89fd6196926be
Quelldatensatz
uspto-grants-1979_03
Patentnummer
US04146539

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