N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine benzyl ester → N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine

HRID 614884

Reaktionsgleichung

Reaktionsgleichung von HRID 614884
C([O:8][C:9](=[O:22])[C@H:10]([CH3:21])[NH:11][C:12](=[O:20])[CH:13]([CH3:19])[CH2:14][C:15]([O:17][CH3:18])=[O:16])C1C=CC=CC=1>C(O)C.[Pd]>[CH3:18][O:17][C:15]([CH2:14][CH:13]([CH3:19])[C:12]([NH:11][C@H:10]([C:9]([OH:22])=[O:8])[CH3:21])=[O:20])=[O:16]

Komponenten

4

Edukt 1

HCID 53826083N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine benzyl ester

Produkt 1

HCID 53969800N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine benzyl ester (50 g.) is dissolved in 95% ethanol, 10% palladium on charcoal (5 g.) is added and the mixture is hydrogenated at normal pressure for 16 hours. The catalyst is filtered off and the filtrate is concentrated to dryness in vacuo to yield N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine.

Aufarbeitung

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-70eff78fb8de4a36a20628967495b140
Quelldatensatz
uspto-grants-1979_03
Patentnummer
US04146641

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