3,3-Dibenzoylpropionic acid ethyl ester → 3,5-Diphenyl-1-(3-pyridyl)-pyrazol-4-acetic acid

HRID 615024

Reaktionsgleichung

Reaktionsgleichung von HRID 615024
C([O:3][C:4](=[O:23])[CH2:5][CH:6]([C:15](=O)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:7](=O)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)C.[NH:24]([C:26]1[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=1)[NH2:25]>C(O)(=O)C>[C:8]1([C:7]2[C:6]([CH2:5][C:4]([OH:3])=[O:23])=[C:15]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:24]([C:26]3[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=3)[N:25]=2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Komponenten

4

Edukt 2

HCID 108524383,3-Dibenzoylpropionic acid ethyl esterHCID 109095193-Hydrazinopyridine

Produkt 1

HCID 205428003,5-Diphenyl-1-(3-pyridyl)-pyrazol-4-acetic acidAusbeute 62 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

8.7 grams 3,3-dibenzoyl-propionic acid ethyl ester, 5.0 grams 3-hydrazino-pyridine and 6.0 grams glacial acetic acid were mixed and the mixture heated to the boiling temperature under reflux for 5 hours. The reaction product was further processed by a procedure analogous to that described in Example (2a). 6.1 grams 3,5-diphenyl-1-(3-pyridyl)-pyrazol-4-acetic acid, melting at 185°-187° C., were obtained, representing a yield of 62%.

Aufarbeitung

  1. temperaturethe mixture heated to the boiling temperature
  2. temperatureunder reflux for 5 hours

Quellen und Nachweise

ORD-Eintrag
ord-8510306f07334b3fbb59502db488a531
Quelldatensatz
uspto-grants-1979_03
Patentnummer
US04146721

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