Sodium borohydride → 4-(2-(2-Hydroxymethylbenzoyl)aminoethylthio]pyridine

HRID 6151Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 6151
[C:1]1(=[O:20])[N:5]([CH2:6][CH2:7][S:8][C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[C:4](=[O:15])[C:3]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:2]12.[BH4-].[Na+].C(O)C.C(OCC)(=O)C>C(O)C>[OH:20][CH2:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:5][CH2:6][CH2:7][S:8][C:9]1[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=1)=[O:15]

Komponenten

5

Edukt 3

HCID 4311764Sodium borohydrideHCID 190792564-(2-Phthalimidoethylthio)pyridineHCID 21584252Ethanol ethylacetate

Produkt 1

HCID 190791794-(2-(2-Hydroxymethylbenzoyl)aminoethylthio]pyridineAusbeute 77,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 2.84 g (10.0 mmol) of 4-(2-phthalimidoethylthio)pyridine in 150 ml of ethanol, 3.78 g (100 mmol) of sodium borohydride was added, and the mixture was stirred at room temperature for 3 hours. The solvent was distilled off and saturated saline was added to the residue. The mixture was extracted with chloroform and the extract was dried over anhydrous magnesium sulfate. The solvent was distilled off and the residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:10 to give 2.24 g of the desired compound (77.8% yield, colorless crystals), mp. 132°-133° C.

Aufarbeitung

  1. distillationThe solvent was distilled off
  2. additionsaturated saline was added to the residue
  3. extractionThe mixture was extracted with chloroform
  4. dry with materialthe extract was dried over anhydrous magnesium sulfate
  5. distillationThe solvent was distilled off
  6. customthe residue was purified by column chromatography (eluent

Quellen und Nachweise

ORD-Eintrag
ord-b2748f3faf0e4cadb94edae14f08f39f
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05246948

Notizen zur Reaktion

Wird geladen…