Hydrochloric Acid → HCID 15580438, Verbindung

HRID 615163Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 615163
Cl.O.C([NH:6][C:7]1[CH:24]=[CH:23][C:10]2[N:11]3[CH:16]=[C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[N:14]=[C:12]3[S:13][C:9]=2[CH:8]=1)(=O)C>COCCO>[NH2:6][C:7]1[CH:24]=[CH:23][C:10]2[N:11]3[CH:16]=[C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[N:14]=[C:12]3[S:13][C:9]=2[CH:8]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 70491659HCID 70491659, Verbindung

Produkt 1

HCID 15580438HCID 15580438, VerbindungAusbeute 83,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80192-MethoxyethanolLösungsmittel

Versuchsvorschrift

To a mixture of 100 ml of concentrated hydrochloric acid solution and 300 ml of methylcellosolve was added 8.5 g of 7-acetamido-2-phenylimidazo[2,1-b]benzothiazole mono-hydrate and the mixture was stirred for 4 hours at 100°-110° C. The reaction mixture was cooled to form crystals, which were recovered by filtration. The crystals were suspended in 200 ml of methylcellosolve and after alkalifying the suspension by adding concentrated aqueous ammonia, 80 ml of water was added to the mixture followed by cooling, thereby crystals precipitated. The crystals precipitated were recovered by filtration and dried to provide 5.76 g of 7-amino-2-phenylimidazo[2,1-b]benzothiazole.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. customto form crystals, which
  3. filtrationwere recovered by filtration
  4. additionby adding concentrated aqueous ammonia, 80 ml of water
  5. additionwas added to the mixture
  6. temperatureby cooling
  7. customcrystals precipitated
  8. customThe crystals precipitated
  9. filtrationwere recovered by filtration
  10. customdried

Quellen und Nachweise

ORD-Eintrag
ord-aeea73616b844914905167f9758f3f60
Quelldatensatz
uspto-grants-1985_02
Patentnummer
US04497817

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