Formaldehyde → 2-(2-Methyl-4-nitrophenyl)propane-1,3-diol

HRID 615274

Reaktionsgleichung

Reaktionsgleichung von HRID 615274
[N+:1]([C:4]1[CH:5]=[C:6]([CH3:11])[C:7]([CH3:10])=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH2:12]=[O:13].[C:14]([O-:17])([O-])=O.[K+].[K+].[O-2].[O-2].[O-2].[Al+3].[Al+3]>CS(C)=O>[CH3:11][C:6]1[CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:9]=[CH:8][C:7]=1[CH:10]([CH2:14][OH:17])[CH2:12][OH:13]

Komponenten

6

Edukt 4

HCID 712FormaldehydeHCID 74404-Nitro-o-xylene2×HCID 11430Potassium CarbonateHCID 9989226Alumina

Produkt 1

HCID 134688462-(2-Methyl-4-nitrophenyl)propane-1,3-diol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Reaktionsbedingungen

Temperatur
500 °C

Versuchsvorschrift

1.2 g (8.0 mmol) 4-Nitro-o-xylene and 0.66 g (22 mmol) paraformaldehyde were added to a mixture of 1.2 g catalyst in 4 ml of dimethylsulphoxide. The catalyst had been prepared by heating for 24 hours at 500° C. a composition containing 20 g K2CO3 per 100 g gamma-alumina, i.e. 2.89 mmol K+ /g Al2O3. The reaction mixture was stirred under nitrogen at 20°-25° C. The conversion of 4-nitro-o-xylene and the selectivity during the reaction were determined by gas-liquid chromatography, whereby the alcohols were analysed via their trimethylsilyl ethers. The results are given in Table I.

Aufarbeitung

  1. customThe catalyst had been prepared

Quellen und Nachweise

ORD-Eintrag
ord-7e4038fb7089486dbf7be45fe60c5ace
Quelldatensatz
uspto-grants-1985_02
Patentnummer
US04497966

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