Chloroacetic Acid → 2-Chloro-N-[2-(dimethylamino)ethyl]acetamide

A suspension of 2-chloroacetic acid (214 mg, 2.27 mmol), PyBOP® (1.18, 2.27 mmol), DIEA (1.18 mL, 6.81 mmol) in CH2Cl2 (1 mL) was stirred at RT for 10-15 minutes. This solution of activated acid was added to a suspension of N1,N1-dimethylethane-1,2-diamine (249 μL, 2.27 mmol) and CH2Cl2 (4 mL). The reaction mixture was stirred at RT for 1.5 h. Diluted with more CH2Cl2 and extracted with H2O (3×). Organic layer was dried under Na2SO4 and concentrated in vacuo to give the desired product 2-chloro-N-(2-(dimethylamino)ethyl)acetamide.

1. stirringThe reaction mixture was stirred at RT for 1.5 h
2. extractionextracted with H2O (3×)
3. customOrganic layer was dried under Na2SO4
4. concentrationconcentrated in vacuo

ORD-Eintrag

ord-f4a83991f4074e9e8925ba811504ad70

Quelldatensatz

uspto-grants-2016_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09440961B2