Ammonium Hydroxide → 4-Methyl-2-phenyloxazole-5-carboxamide

HRID 616014Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 616014
[OH-].[NH4+:2].[C:3]([C:8]1[O:12][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:10][C:9]=1[CH3:19])(OCC)=[O:4]>C(O)C>[C:3]([C:8]1[O:12][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:10][C:9]=1[CH3:19])(=[O:4])[NH2:2]

Komponenten

4

Edukt 2

HCID 14923Ammonium HydroxideHCID 12282208ethyl 4-methyl-2-phenyl-1,3-oxazole-5-carboxylate

Produkt 1

HCID 727634-Methyl-2-phenyloxazole-5-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

150 Ml. (2.5 mole) of concentrated ammonium hydroxide is added dropwise to a solution of 10 g. (0.0434 mole) of 5-carbethoxy-2-phenyl-4-methyloxazole in 150 ml. of 95% ethanol. The mixture is stirred three days at room temperature, then it is concentrated to 50 ml. by evaporating the ethanol and chilled. The precipitated product is filtered, washed, dried over sodium sulfate and recrystallized from methanol; yield 3.7 g. of the title compound; m.p. 187°-190°.

Aufarbeitung

  1. concentrationit is concentrated to 50 ml
  2. customby evaporating the ethanol
  3. temperaturechilled
  4. filtrationThe precipitated product is filtered
  5. washwashed
  6. dry with materialdried over sodium sulfate
  7. customrecrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-41a18a3b133e47a28f4c0d53ffcb7d5b
Quelldatensatz
uspto-grants-1978_02
Patentnummer
US04072689

Notizen zur Reaktion

Wird geladen…