2-Amino-4-methylpyridine → 1,2-Diphenyl-3,5-dioxo-4-n-butylpyrazolidine 2-amino-4-methyl-pyridine

HRID 616146

Reaktionsgleichung

Reaktionsgleichung von HRID 616146
[C:1]1([N:7]2[C:11](=[O:12])[CH:10]([CH2:13][CH2:14][CH2:15][CH3:16])[C:9](=[O:17])[N:8]2[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:24][C:25]1[CH:30]=[C:29]([CH3:31])[CH:28]=[CH:27][N:26]=1>CC(C)=O>[C:1]1([N:7]2[C:11](=[O:12])[CH:10]([CH2:13][CH2:14][CH2:15][CH3:16])[C:9](=[O:17])[N:8]2[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1.[NH2:24][C:25]1[CH:30]=[C:29]([CH3:31])[CH:28]=[CH:27][N:26]=1

Komponenten

4

Edukt 2

HCID 15332-Amino-4-methylpyridineHCID 4781Phenylbutazone

Produkt 1

HCID 867342191,2-Diphenyl-3,5-dioxo-4-n-butylpyrazolidine 2-amino-4-methyl-pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel2×

Versuchsvorschrift

30.8 g (0.1 mol) of 1,2-diphenyl-3,5-dioxo-4-butyl-pyrazolidine are introduced with agitation into a 500 cc flask and mixed with 150 ml of acetone until complete dissolution. 10.8 g (0.1 mol) of 2-amino-4-methylpyridine which have previously been dissolved in 100 cc of acetone are then added and the mixture is boiled for 30 minutes. It is filtered cold, and 39 g of a product having a melting point of 121°-2° C are crystallized out.

Aufarbeitung

  1. additionare then added
  2. filtrationIt is filtered cold
  3. customare crystallized out

Quellen und Nachweise

ORD-Eintrag
ord-7392f2e101d54347bd569339fc5a34c4
Quelldatensatz
uspto-grants-1978_02
Patentnummer
US04072747

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