Dopac → HCID 21851548, Verbindung

HRID 617181

Reaktionsgleichung

Reaktionsgleichung von HRID 617181
[NH2:1][C:2]1[N:11]=[C:10]([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[OH:18][C:19]1[CH:20]=[C:21]([CH2:26][C:27](O)=[O:28])[CH:22]=[CH:23][C:24]=1[OH:25]>CN(C)C1C=CN=CC=1.CN(C)C=O>[NH2:1][C:2]1[N:11]=[C:10]([CH:12]2[CH2:17][CH2:16][N:15]([C:27](=[O:28])[CH2:26][C:21]3[CH:22]=[CH:23][C:24]([OH:25])=[C:19]([OH:18])[CH:20]=3)[CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Komponenten

5

Edukt 2

HCID 547DopacHCID 15428775HCID 15428775, Verbindung

Produkt 1

HCID 21851548HCID 21851548, VerbindungAusbeute 60,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To an ice-cold solution of 2-amino-4-(4-piperidinyl)quinazoline (600 mg, 2.63 mmol) obtained in example 11(1), 3,4-dihydroxyphenylacetic acid (530 mg, 3.16 mmol) and 4-dimethylaminopyridine (386 mg, 3.16 mmol) in dimethylformamide (20 ml) was added 1-ethyl-3-(N,N'-dimethylaminopropyl)carbodiimide hydrochloride (605 mg, 3.16 mmol) under a nitrogen atmosphere. The mixture was stirred overnight at room temperature. The solvent was removed in vacuo and the residue was crystallized from methanol to give the titled compound (599 mg).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe residue was crystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-1a25b87a62d743c3ad64eaa5fa0c8dcd
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05948786

Verknüpfte Notizen

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