Ammonium Hydroxide → 5-Pyrimidinecarboxylic acid, 4-amino-2-(methylthio)-, ethyl ester

HRID 617960

Reaktionsgleichung

Reaktionsgleichung von HRID 617960
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]([S:13][CH3:14])[N:3]=1.[OH-].[NH4+:16]>C(O)C>[CH2:11]([O:10][C:8]([C:7]1[C:2]([NH2:16])=[N:3][C:4]([S:13][CH3:14])=[N:5][CH:6]=1)=[O:9])[CH3:12]

Komponenten

4

Edukt 2

HCID 14923Ammonium HydroxideHCID 800084-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester

Produkt 1

HCID 2226665-Pyrimidinecarboxylic acid, 4-amino-2-(methylthio)-, ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a suspension of ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate (25 g) in ethanol (200 mL) was added 30% ammonium hydroxide (38 mL). After stirring 5 hours at room temperature, the reaction was concentrated in vacuo. The residue was suspended in water and filtered. The filter pad, washed with water then diethyl ether, gave 17.68 g of the title compound, CIMS (1% NH3 in CH4): 242=M+ +C2H5, 214=M+ +H (Base), 213=M+, 168=M+ -OEt.

Aufarbeitung

  1. concentrationthe reaction was concentrated in vacuo
  2. filtrationfiltered
  3. washThe filter pad, washed with water

Quellen und Nachweise

ORD-Eintrag
ord-02618b0e8ba54692afa0e06d45d27c93
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05952342

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