Water → (2,6-Dimethyl-3-nitrophenyl)methanol

HRID 618239

Reaktionsgleichung

Reaktionsgleichung von HRID 618239
[CH3:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([CH3:14])[C:3]=1[C:4](O)=[O:5].B.O>O1CCCC1>[CH3:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([CH3:14])[C:3]=1[CH2:4][OH:5]

Komponenten

5

Edukt 3

HCID 962WaterHCID 6331BoraneHCID 2393292,6-Dimethyl-3-nitrobenzoic acid

Produkt 1

HCID 10487641(2,6-Dimethyl-3-nitrophenyl)methanolAusbeute 93,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

2,6-Dimethyl-3-nitrobenzoic acid (10 g) was dissolved in 100 ml of dry tetrahydrofuran and 165 ml of 1M borane in tetrahydrofuran added. The mixture was heated to 75° C. for 4 hr. The mixture was cooled to room temperature and the excess reagent slowly decomposed with water and the solvent evaporated. The residue was treated with ethyl acetate, washed with 1M hydrochloric acid, then with water, dried, and evaporated to give 8.71 g of (2,6-dimethyl-3-nitro-phenyl)-methanol, mp 94.5-96.1° C. ##STR124##

Aufarbeitung

  1. temperatureThe mixture was cooled to room temperature
  2. customthe solvent evaporated
  3. additionThe residue was treated with ethyl acetate
  4. washwashed with 1M hydrochloric acid
  5. dry with materialwith water, dried
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-57dc12dc7ae8494196565dd1f0c22521
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05952362

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