Diethyl Ether → Methyl 2-methoxy-3-nitrobenzoate

HRID 618242Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 618242
O[C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7]C=1C(O)=O.IC.[C:16](=[O:19])([O-])[O-].[K+].[K+].C[CH2:23][O:24][CH2:25][CH3:26].CN(C)C=[O:30]>>[CH3:23][O:24][C:25](=[O:30])[C:26]1[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:2]=1[O:19][CH3:16]

Komponenten

6

Edukt 5

HCID 3283Diethyl EtherHCID 6228DimethylformamideHCID 6328Methyl iodideHCID 68073-Nitrosalicylic acidHCID 11430Potassium Carbonate

Produkt 1

HCID 590805Methyl 2-methoxy-3-nitrobenzoate

Reaktionsbedingungen

Temperatur
45 °C

Versuchsvorschrift

A solution of 15 g of 2-hydroxy-3-nitro-benzoic acid in 200 ml of N,N-dimethylformamide was treated with 58.1 g of iodomethane and 56.6 g of potassium carbonate, and the resultant heterogeneous mixture was stirred and heated to 45° C. for 20 hr. The mixture was cooled to room temperature, poured into ether, washed with water, washed with saturated sodium carbonate solution, washed with water, dried over magnesium sulfate, evaporated, and 14.2 g of 2-methoxy-3-nitro-benzoic acid methyl ester obtained as an oil which crystallized to a white solid. ##STR135##

Aufarbeitung

  1. temperatureThe mixture was cooled to room temperature
  2. washwashed with water
  3. washwashed with saturated sodium carbonate solution
  4. washwashed with water
  5. dry with materialdried over magnesium sulfate
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-ba6db051f99e446099d47640d714d522
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05952362

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