Triethylamine → 3-(4-Trifluoromethylbenzamido)propan-1-ol

HRID 618406

Reaktionsgleichung

Reaktionsgleichung von HRID 618406
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].C(N(CC)CC)C.[F:13][C:14]([F:25])([F:24])[C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1>ClCCl>[F:13][C:14]([F:24])([F:25])[C:15]1[CH:23]=[CH:22][C:18]([C:19]([NH:1][CH2:2][CH2:3][CH2:4][OH:5])=[O:20])=[CH:17][CH:16]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 90863-Amino-1-propanolHCID 676074-(Trifluoromethyl)benzoyl chloride

Produkt 1

HCID 220068303-(4-Trifluoromethylbenzamido)propan-1-olAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A reaction vessel was charged with 7.51 g of 3-amino-1-propanol, 2.53 g of triethylamine and 50 ml of dichloromethane, and 5.21 g of 4-trifluoromethylbenzoyl chloride was slowly added dropwise under ice cooling. After stirring at room temperature for 6 hours, the reaction mixture was successively washed with diluted hydrochloric acid and water, dried over anhydrous magnesium sulfate, and then concentrated, which afforded 5.25 g of 3-(4-trifluoromethylbenzamido)propan-1-ol (85% yield).

Aufarbeitung

  1. additionwas slowly added dropwise under ice cooling
  2. washthe reaction mixture was successively washed with diluted hydrochloric acid and water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-76ee336123e34623bfc57fb3c8e6cf87
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05952386

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