HCID 21847506, Verbindung → 6-Methyl-2-pyridylpropan-1-ol

HRID 618626

Reaktionsgleichung

Reaktionsgleichung von HRID 618626
[CH3:1][C:2]1[N:7]=[C:6]([CH2:8][C:9]#[C:10][OH:11])[CH:5]=[CH:4][CH:3]=1>CO.O=[Pt]=O>[CH3:1][C:2]1[N:7]=[C:6]([CH2:8][CH2:9][CH2:10][OH:11])[CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 21847506HCID 21847506, Verbindung

Produkt 1

HCID 1091326-Methyl-2-pyridylpropan-1-olAusbeute 77 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

3-(6-methyl -2-pyridyl)propyn-1-ol was dissolved in MeOH (100 mL) and PtO2 (0.09 g) was added. The reaction mixture was hydrogenated at 4 atm for 30 min. The catalyst was filtered off and methanol evaporated in vacuo. The orange oily residue (2 g) was purified by column chromatography (silica gel, ethyl acetate) yielding a yellow oil (77%). MS (DCI) (M+H)+ at m/z 152.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. custommethanol evaporated in vacuo
  3. customThe orange oily residue (2 g) was purified by column chromatography (silica gel, ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-e5d6e047d2f744598b83c134f1b1aa1e
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05955440

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