Triethylamine → N-(2-mesitylenesulfonyl)-p-styrenesulfonamide

HRID 618960

Reaktionsgleichung

Reaktionsgleichung von HRID 618960
[CH2:1]=[CH:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH2:12])(=[O:11])=[O:10])=[CH:5][CH:4]=1.C(N(CC)CC)C.[C:20]1([CH3:32])[CH:25]=[C:24]([CH3:26])[CH:23]=[C:22]([CH3:27])[C:21]=1[S:28](Cl)(=[O:30])=[O:29]>CN(C1C=CN=CC=1)C.C(#N)C>[C:20]1([CH3:32])[CH:25]=[C:24]([CH3:26])[CH:23]=[C:22]([CH3:27])[C:21]=1[S:28]([NH:12][S:9]([C:6]1[CH:5]=[CH:4][C:3]([CH:2]=[CH2:1])=[CH:8][CH:7]=1)(=[O:11])=[O:10])(=[O:29])=[O:30]

Komponenten

6

Edukt 3

HCID 8471TriethylamineHCID 130462-Mesitylenesulfonyl chlorideHCID 2809354-(Sulfonamido)styrene

Produkt 1

HCID 21845203N-(2-mesitylenesulfonyl)-p-styrenesulfonamideAusbeute 64,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Using 55.0 g (0.3 mol) of p-styrenesulfonamide, 3.7 g (0.03 mol) of 4-(N,N-dimethylamino)pyridine, 82.0 g (0.81 mol) of triethylamine, 91.8 g (0.42 mol) of 2-mesitylenesulfonyl chloride, and 500 ml of acetonitrile, reaction was conducted in the same manner as in Synthesis Example 1. As a result, 70.9 g of N-(2-mesitylenesulfonyl) -p-styrenesulfonamide was obtained (yield, 64.7%; light-yellow crystals; m.p., 146.5-147° C.).

Aufarbeitung

  1. customwas conducted in the same manner as in Synthesis Example 1

Quellen und Nachweise

ORD-Eintrag
ord-d9011c8d0ac64ae9b12a0f6d68f23ef9
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05958646

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