Benzofuran → HCID 66835117, Verbindung

HRID 61914

Reaktionsgleichung

Reaktionsgleichung von HRID 61914
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10](O)([CH3:12])[CH3:11].[CH:14]1[CH:19]=[C:18]2[CH:20]=[CH:21][O:22][C:17]2=[CH:16][CH:15]=1>O>[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]([C:21]1[O:22][C:17]2[CH:16]=[CH:15][CH:14]=[CH:19][C:18]=2[CH:20]=1)([CH3:12])[CH3:11]

Komponenten

4

Edukt 2

HCID 9223BenzofuranHCID 66834833HCID 66834833, Verbindung

Produkt 1

HCID 66835117HCID 66835117, VerbindungAusbeute 51 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

Mixture comprising 2-(2-bromo-4-methoxyphenyl)-propan-2-ol (100 mg), 2,3-benzofuran (0.19 ml) and polyphosphoric acid (1 g) was stirred and heated at 90° C. for 30 min. The reaction mixture was added with water and extracted with DCM. The residues obtained after concentration under reduced pressure were purified by silica gel column (DCM/hexane) to obtain the title compound (143 mg, 51%).

Aufarbeitung

  1. extractionextracted with DCM
  2. customThe residues obtained
  3. concentrationafter concentration under reduced pressure
  4. customwere purified by silica gel column (DCM/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-2849a2275abf4a2981c23ec3f6fc2aca
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440922B2

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