N,N-Dimethyl-1,3-propanediamine → HCID 59355218, Verbindung

HRID 61977Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 61977
[CH3:1][CH:2]1[CH2:7][CH:6]([CH3:8])[CH2:5][N:4]([S:9]([C:12]2[CH:25]=[CH:24][C:23]3[N:22]([CH3:26])[C:21]4[C:16](=[CH:17][C:18]([S:27]([N:30]5[CH2:35][CH:34]([CH3:36])[CH2:33][CH:32]([CH3:37])[CH2:31]5)(=[O:29])=[O:28])=[CH:19][CH:20]=4)[C:15](=S)[C:14]=3[CH:13]=2)(=[O:11])=[O:10])[CH2:3]1.[CH3:39][N:40]([CH2:42][CH2:43][CH2:44][NH2:45])[CH3:41]>N1C=CC=CC=1>[CH3:36][CH:34]1[CH2:33][CH:32]([CH3:37])[CH2:31][N:30]([S:27]([C:18]2[CH:19]=[CH:20][C:21]3[N:22]([CH3:26])[C:23]4[C:14](=[CH:13][C:12]([S:9]([N:4]5[CH2:3][CH:2]([CH3:1])[CH2:7][CH:6]([CH3:8])[CH2:5]5)(=[O:11])=[O:10])=[CH:25][CH:24]=4)[C:15](=[N:45][CH2:44][CH2:43][CH2:42][N:40]([CH3:41])[CH3:39])[C:16]=3[CH:17]=2)(=[O:28])=[O:29])[CH2:35]1

Komponenten

4

Edukt 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 59355205HCID 59355205, Verbindung

Produkt 1

HCID 59355218HCID 59355218, VerbindungAusbeute 85,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridine-9(10H) thione (145 mg, 0.25 mmole), pyridine (5 mL) and dimethylaminopropylamine (0.125 mL, 1 mmole) was stirred at 100° C. for 4 hrs. Solvent was partially evaporated and reaction product was precipitated by addition of methanol. Precipitate was collected by filtration, washed with methanol and dried to give 137 mg (85%) of the title compound. MS 644 (MH+).

Aufarbeitung

  1. customSolvent was partially evaporated
  2. customreaction product
  3. customwas precipitated by addition of methanol
  4. filtrationPrecipitate was collected by filtration
  5. washwashed with methanol
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a438b9687ebd46e19da4049e78d91fe2
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09446021B2

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