Acetone → 3-chloro-N-phenylpropanamide

HRID 620008Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 620008
[Cl:1][CH2:2][CH2:3][C:4](Cl)=[O:5].CC(C)=O.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.Cl>O>[Cl:1][CH2:2][CH2:3][C:4]([NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:5]

Komponenten

6

Edukt 4

HCID 180Acetone2×HCID 313Hydrochloric AcidHCID 6115AnilineHCID 693643-Chloropropionyl chloride

Produkt 1

HCID 2404043-chloro-N-phenylpropanamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 3-chloropropionyl chloride (300 ml) and acetone (600 ml) is added dropwise to a refluxing mixture of aniline (575 ml) and acetone (600 ml). The reaction mixture is refluxed for one hour, cooled in an ice bath, and poured into a mixture of 6N HCl (500 ml) and water (3.5 l). The resulting solid is filtered, washed with water, and dried, yielding the desired product, M.P. 114°-115.5° C.

Aufarbeitung

  1. temperatureThe reaction mixture is refluxed for one hour
  2. temperaturecooled in an ice bath
  3. filtrationThe resulting solid is filtered
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-6d3202c895954af697ce840462fbfe2a
Quelldatensatz
uspto-grants-1989_04
Patentnummer
US04818755

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