Chloroacetic Acid → 2-(chloromethyl)-1-(3-fluorophenyl)-1H-1,3-benzodiazole

HRID 620034Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 620034
[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH2:15])[CH:5]=[CH:6][CH:7]=1.[Cl:16][CH2:17][C:18](O)=O.C(=O)([O-])[O-].[Na+].[Na+]>O>[F:1][C:2]1[CH:3]=[C:4]([N:8]2[C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:15]=[C:18]2[CH2:17][Cl:16])[CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 300Chloroacetic AcidHCID 10340Sodium CarbonateHCID 21248421HCID 21248421, Verbindung

Produkt 1

HCID 212484162-(chloromethyl)-1-(3-fluorophenyl)-1H-1,3-benzodiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

A mixture of N-(3-fluorophenyl)-o-phenylenediamine (0.8 g, 4 mmol) prepared in the preceding step (a), polyphosphoric ester (2.7 g) and monochloroacetic acid (0.4 g, 4.2 mmol) was heated for 1 hour at 130° C. and water was added to the reaction mixture to decompose an excess of polyphosphoric ester, then neutralized with sodium carbonate and the occurred oily substance was extracted with chloroform and the extract was washed, dried and concentrated in vacuo.

Aufarbeitung

  1. extractionthe occurred oily substance was extracted with chloroform
  2. washthe extract was washed
  3. customdried
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c8562ea73a6143e88762b9fffa07ae2d
Quelldatensatz
uspto-grants-1989_04
Patentnummer
US04818761

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