Water → 7-bromo-2H,3H,4H-pyrido(3,2-b)(1,4)oxazin-3-one
Reaktionsgleichung
[O:1]1[CH2:6][C:5](=[O:7])[NH:4][C:3]2[N:8]=[CH:9][CH:10]=[CH:11][C:2]1=2.C1C(=O)N([Br:19])C(=O)C1.O>CN(C=O)C>[Br:19][C:10]1[CH:9]=[N:8][C:3]2[NH:4][C:5](=[O:7])[CH2:6][O:1][C:2]=2[CH:11]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 5.6 g 2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one dissolved in 85 ml of DMF under nitrogen is added 7.96 g NBS in 50 ml of DMF. This is allowed to stir at room temperature overnight. To this is added 35 ml of water and chilled. The solid material which separates is filtered and washed with 3×100 ml H2O. This is then dried in a vac oven at 70° C. and then used directly in the next step.
Aufarbeitung
- temperaturechilled
- filtrationThe solid material which separates is filtered
- washwashed with 3×100 ml H2O
- customThis is then dried in a vac oven at 70° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-d9186c55e6df456c9567364e7b35f770
- Quelldatensatz
- uspto-grants-1989_04
- Patentnummer
- US04822794
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