Reaktionsgleichung
Cl.[CH2:2]([C@H:7]1[CH2:12][CH2:11][C@H:10]([C:13]([NH2:15])=[NH:14])[CH2:9][CH2:8]1)[CH2:3][CH2:4][CH2:5][CH3:6].[CH3:16][O:17][CH:18]([C:23](OC)=[O:24])[C:19](OC)=[O:20].C[O-].[Na+].Cl>CO>[CH2:2]([C@H:7]1[CH2:8][CH2:9][C@H:10]([C:13]2[N:15]=[C:23]([OH:24])[C:18]([O:17][CH3:16])=[C:19]([OH:20])[N:14]=2)[CH2:11][CH2:12]1)[CH2:3][CH2:4][CH2:5][CH3:6]Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
This trans-4-pentylcyclohexanecarboxamidine hydrochloride (69 g, 0.30 mol) and dimethyl methoxymalonate (48 g, 0.30 mol) were added to a solution of sodium methylate (56 g, 1.0 mol) dissolved in anhydrous methanol (1 l), followed by heating the mixture under reflux with stirring for 5 hours, thereafter cooling the resulting material, mixing it with 6N-hydrochloric acid (500 ml), agitating the mixed liquid at room temperature for 20 minutes, filtering the liquid under suction through a filter, washing the resulting residue on the filter with water and methanol and drying it under reduced pressure to obtain 2-(trans-4-pentylcyclohexyl)-4,6-dihydroxy-5-methoxypyrimidine (67 g, 0.23 mol).
Aufarbeitung
- temperatureby heating the mixture
- temperatureunder reflux
- temperaturecooling the resulting material
- stirringagitating the mixed liquid at room temperature for 20 minutes
- filtrationfiltering the liquid under suction through a filter
- washwashing the resulting residue on the
- filtrationfilter with water and methanol
- customdrying it under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-75d317e262074094992716415ffca4bd
- Quelldatensatz
- uspto-grants-1989_04
- Patentnummer
- US04824596
Verknüpfte Notizen
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