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Isobutyraldehyde → 2-Methylpropyl 3-carbamoylmethyl-Beta-hydroxy2-(1-methylethyl)-4-oxo-1-imidazolidinebutanoate

HRID 621601
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 621601
C(O)(=O)C.[NH2:5][CH2:6][C:7]([NH:9][CH2:10][C:11]([NH2:13])=[O:12])=[O:8].[CH:14](=O)[CH:15]([CH3:17])[CH3:16].C(=O)([O-])[O-].[Na+].[Na+].[O:25]1[CH2:35][CH:26]1[CH2:27][C:28]([O:30][CH2:31][CH:32]([CH3:34])[CH3:33])=[O:29]>CO.O>[C:11]([CH2:10][N:9]1[C:7](=[O:8])[CH2:6][N:5]([CH2:35][CH:26]([OH:25])[CH2:27][C:28]([O:30][CH2:31][CH:32]([CH3:34])[CH3:33])=[O:29])[CH:14]1[CH:15]([CH3:17])[CH3:16])(=[O:12])[NH2:13]
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Komponenten

7

Edukt 4

HCID 6561IsobutyraldehydeHCID 10340Sodium CarbonateHCID 5463767Isobutyl 3,4-epoxybutyrateHCID 19850195Glycylglycinamide acetate

Produkt 1

HCID 146180242-Methylpropyl 3-carbamoylmethyl-Beta-hydroxy2-(1-methylethyl)-4-oxo-1-imidazolidinebutanoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962
Water
Katalysator
HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 1.91 g (0.01 mol) of glycylglycinamide acetate and 0.72 g (0.01 mol) of isobutyraldehyde in 40 ml of methanol was stirred for 24 hours at room temperature. The solvent was evaporated under reduced pressure and the residue was dissolved in 30 ml of isopropanol and treated with 0.106 g of sodium carbonate, 1.8 g (0.0115 mol) of 2-methylpropyl 3,4-epoxybutanoate and 2 drops of water. The mixture was refluxed for 36 hours. After evaporation of the solvent the residue was chromatographed on a silica gel column, eluting with dichloromethane/methanol 9:1. The title compound (0.48 g) was constituted by two diastereoisomers.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionthe residue was dissolved in 30 ml of isopropanol
  3. temperatureThe mixture was refluxed for 36 hours
  4. customAfter evaporation of the solvent the residue
  5. customwas chromatographed on a silica gel column
  6. washeluting with dichloromethane/methanol 9:1

Quellen und Nachweise

ORD-Eintrag
ord-753f2223352b4ab9a69f29d159f20695
Quelldatensatz
uspto-grants-1989_04
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04824861

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