Ethyl Acetoacetate → Methyl 3-hydroxy-5-methylthiophene-2-carboxylate

HRID 621783Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 621783
[C:1]([O:7][CH2:8]C)(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[C:10](OC)(=O)[CH2:11][SH:12].[Na]>ClCCl>[OH:4][C:3]1[CH:5]=[C:11]([CH3:10])[S:12][C:2]=1[C:1]([O:7][CH3:8])=[O:6]

Komponenten

5

Edukt 3

HCID 8868Ethyl AcetoacetateHCID 16907Methyl ThioglycolateHCID 5360545Sodium

Produkt 1

HCID 587860Methyl 3-hydroxy-5-methylthiophene-2-carboxylateAusbeute 52,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Prepared by the method described in Example 1 from ethyl acetoacetate (130 g, 1.0 mole), methyl thioglycolate (212 g, 2.0 moles) and sodium (53 g, 2.3 moles). The crude product is shaken with two portions of dichloromethane, filtered, and the filtrate stripped of solvent under reduced pressure to afford the product (90.1 g); mp 50°-53° C.

Aufarbeitung

  1. customPrepared by the method
  2. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-a0d5afd534c549998c46e0ca23cb59e2
Quelldatensatz
uspto-grants-1989_04
Patentnummer
US04824958

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