Hydrochloric Acid → 2-(4-Carbamoyloxypiperidin-1-yl)-2-iminoethylmercaptan hydrochloride

HRID 622426Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 622426
P(=[S:5])([O-])([O-])[O-].[Na+].[Na+].[Na+].Cl.[C:10]([O:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20](=[NH:23])[CH2:21][Cl:22])[CH2:16][CH2:15]1)(=[O:12])[NH2:11].Cl>O>[ClH:22].[C:10]([O:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20](=[NH:23])[CH2:21][SH:5])[CH2:16][CH2:15]1)(=[O:12])[NH2:11]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 9877537Trisodium thiophosphateHCID 212930032-(4-Carbamoyloxypiperidin-1-yl)-2-iminoethylchloride hydrochloride

Produkt 1

HCID 212929412-(4-Carbamoyloxypiperidin-1-yl)-2-iminoethylmercaptan hydrochlorideAusbeute 97,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

4.95 g of trisodium phosphorothioate were added to an ice-cooled solution of 6.40 g of 2-(4-carbamoyloxypiperidin-1-yl)-2-iminoethylchloride hydrochloride in 32 ml of water, and the mixture was stirred at room temperature for 2.5 hours. 28 ml of 1N hydrochloric acid were then added, and the mixture was heated at 60° C. for 30 minutes. The reaction mixture was worked up in the same manner as in Example 1(2), giving 6.20 g of 2-(4-carbamoyloxypiperidin-1-yl)-2-iminoethylmercaptan hydrochloride.

Aufarbeitung

  1. temperaturethe mixture was heated at 60° C. for 30 minutes

Quellen und Nachweise

ORD-Eintrag
ord-28b83350812a47d291f101b3e858f52d
Quelldatensatz
uspto-grants-1988_09
Patentnummer
US04771046

Notizen zur Reaktion

Wird geladen…