Hydrochloric Acid → 2-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylmercaptan hydrochloride

HRID 622429Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 622429
P(=[S:5])([O-])([O-])[O-].[Na+].[Na+].[Na+].Cl.[C:10]([CH:13]1[CH2:18][CH2:17][CH2:16][N:15]([C:19](=[NH:22])[CH2:20][Cl:21])[CH2:14]1)(=[O:12])[NH2:11].Cl>O>[ClH:21].[C:10]([CH:13]1[CH2:18][CH2:17][CH2:16][N:15]([C:19](=[NH:22])[CH2:20][SH:5])[CH2:14]1)(=[O:12])[NH2:11]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 9877537Trisodium thiophosphateHCID 212929612-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylchloride hydrochloride

Produkt 1

HCID 212929852-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylmercaptan hydrochlorideAusbeute 105,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1.43 g of trisodium phosphorothioate were added to an ice-cooled solution of 2.04 g of 2-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylchloride hydrochloride in 9.7 ml of water, and the mixture was stirred at room temperature for one hour. 7.9 ml of 1N hydrochloric acid were then added, and the mixture was heated at 50° C. for 30 minutes. The reaction mixture was then worked up in the same manner as in Example 3(2) to give 2.0 g of 2-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylmercaptan hydrochloride.

Aufarbeitung

  1. temperaturethe mixture was heated at 50° C. for 30 minutes

Quellen und Nachweise

ORD-Eintrag
ord-a8211e0cf8f2420599fee0cf2bb665cb
Quelldatensatz
uspto-grants-1988_09
Patentnummer
US04771046

Notizen zur Reaktion

Wird geladen…