Hydrochloric Acid → HCID 178524721, Verbindung

HRID 622696Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 622696
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:17])=[C:7]([C:12]([O:14]CC)=[O:13])[CH:8]=[N:9]2)=[CH:4][C:3]=1[F:18].[OH-].[Na+].Cl>O>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:17])=[C:7]([C:12]([OH:14])=[O:13])[CH:8]=[N:9]2)=[CH:4][C:3]=1[F:18]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 3018009Ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Produkt 1

HCID 178524721HCID 178524721, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of ethyl 7-chloro-6-fluoro-4-hydroxyquinoline-3-carboxylate (67 g), sodium hydroxide (12 g), water (350 ml) and industrial methylated spirit (175 ml) was boiled under reflux for 65 hours. The mixture was cooled to ambient temperature and acidified to pH 1 with concentrated hydrochloric acid. The resulting precipitate was collected, washed with water and dried to give the novel compound 7-chloro-6-fluoro-4-hydroxyquinoline-3-carboxylic acid, m.p. 263°-265° (dec).

Aufarbeitung

  1. temperatureunder reflux for 65 hours
  2. customThe resulting precipitate was collected
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-988935ef9d5c4ccb91de2d689f8c55fa
Quelldatensatz
uspto-grants-1988_09
Patentnummer
US04772614

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