HCID 86704207, Verbindung → 1-[2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-ethyl]-1H-pyrazol-4-ylamine

HRID 624013Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 624013
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][CH2:12][CH2:13][N:14]2[CH:18]=[C:17]([N+:19]([O-])=O)[CH:16]=[N:15]2)[N:4]=1>CCOC(C)=O.CCO.O=[Pt]=O>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([O:11][CH2:12][CH2:13][N:14]2[CH:18]=[C:17]([NH2:19])[CH:16]=[N:15]2)[N:6]=1

Komponenten

5

Edukt 1

HCID 86704207HCID 86704207, Verbindung

Produkt 1

HCID 682827731-[2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-ethyl]-1H-pyrazol-4-ylamine

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 345198Adams' catalystKatalysatorHCID 702EthanolLösungsmittel2×HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 4,6-dimethoxy-2-(2-(4-nitro-1H-pyrazol-1-yl)ethoxy)pyrimidine (2.05 g, 6.93 mmol), in EtOAc (3.0 mL, degassed) and EtOH (9 mL, degassed), PtO2 (135 mg, 0.70 mmol) was added and the reaction mixture was stirred at rt under a H2-atmosphere for 3 h. The mixture was diluted with EtOH, filtered over celite and the filter cake was rinsed with EtOH. The filtrate was concentrated to obtain the title compound as a red oil. LC-MS conditions A: tR=0.58 min, [M+H]+=266.02.

Aufarbeitung

  1. filtrationfiltered over celite
  2. washthe filter cake was rinsed with EtOH
  3. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-1c04a8914b4b45e5958600a82c0491af
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303023B2

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