1-(3-(4-nitro-1H-pyrazol-1-yl)propyl)indoline → 1-[3-(2,3-Dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine

HRID 624023Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 624023
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][CH2:11][N:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:14][CH2:13]2)[CH:8]=1)([O-])=O>[Pd].CO>[N:12]1([CH2:11][CH2:10][CH2:9][N:7]2[CH:8]=[C:4]([NH2:1])[CH:5]=[N:6]2)[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13]1

Komponenten

4

Edukt 1

HCID 867042081-(3-(4-nitro-1H-pyrazol-1-yl)propyl)indoline

Produkt 1

HCID 682827791-[3-(2,3-Dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a round bottom flask was added 1-(3-(4-nitro-1H-pyrazol-1-yl)propyl)indoline (2.10 g, 7.70 mmol), Pd/C (210 mg) and MeOH (48 mL, degassed). The flask was evacuated and backfilled with H2 and the reaction mixture was stirred under H2-atmosphere at rt for 18 h. The reaction mixture was filtered over celite, washed with MeOH and the solvent was removed under reduced pressure to yield the title compound as a red oil. LC-MS conditions

Aufarbeitung

  1. customThe flask was evacuated
  2. filtrationThe reaction mixture was filtered over celite
  3. washwashed with MeOH
  4. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ed6c4acc10cd46c1b28db97edcb830d6
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303023B2

Notizen zur Reaktion

Wird geladen…